neuronal differentiation
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Malformation of cortical development: the genesis of epileptogenic networks
Malformations of cortical development (MCDs) result from alterations of one or combined developmental steps, including progenitors proliferation, neuronal migration and differentiation. They are important cause of childhood epilepsy and frequently associate cognitive deficits and behavioral alterations. Though the genetic basis of MCDs have known prominent progress during the past decade, including the identification of somatic, mosaic mutations responsible for focal MCDs, the pathophysiological mechanisms linking malformations to epileptogenesis remain elusive. In this seminar I will present data from my team and from the literature addressing this topic in two different MCDs types, the subcortical band heterotopia as a model of cortical migration defect and mTOR- dependent MCDs , that characterize by cortical dyslamination and neuronal differentiation defects.
INFLUENCE OF THE EXTRACELLULAR MICROENVIRONMENT ON NEURONAL DIFFERENTIATION OF URINE-DERIVED STEM CELLS
FENS Forum 2026
SELECTIVE DISRUPTION OF THE CELLULAR MACHINERY TO DISSECT NEURONAL DIFFERENTIATION
FENS Forum 2026
TBR2 COORDINATES ATP-DEPENDENT CHROMATIN REMODELING REQUIRED FOR NEURONAL DIFFERENTIATION IN HUMAN CORTICAL ORGANOIDS
FENS Forum 2026
ALZHEIMER-CAUSING <EM >PSEN1</EM> MUTATIONS INTERFERE WITH EARLY NEURONAL DIFFERENTIATION IN A HUMAN IPSC-DERIVED MODEL FOR NEURODEVELOPMENT
FENS Forum 2026
SYSTEMATIC IN UTERO CRISPR SCREENING IDENTIFIES TRANSCRIPTIONAL CONTROL OF CLASS-SPECIFIC NEURONAL DIFFERENTIATION IN THE NEOCORTEX
FENS Forum 2026
Expression of novel TLK2 isoforms during neuronal differentiation
FENS Forum 2024
A Neurofilament-L reporter cell line for the quantification of early neuronal differentiation: A bioassay for neurotrophic activities
FENS Forum 2024
Optimizing serum-free neuronal differentiation of SH-SY5Y cells: Implications for Alzheimer's disease therapy
FENS Forum 2024
Semaphorin 3A regulates axon growth cone elongation during neuronal differentiation
Is dysfunctional neuronal differentiation the link between diet and neurodegeneration?
FENS Forum 2024
Exploring the contribution of BRI2 expression and proteolytic processing on neuronal differentiation
FENS Forum 2024
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