neuronal hyperexcitability

Digging Deep: Uncovering Hidden Connections Between Epilepsy and Alzheimer’s Disease

An emerging hypothesis in the field of Alzheimer’s disease (AD) is that neuronal hyperexcitability and other forms of aberrant network activity play an important role in shaping the clinical course of AD. In this talk, Dr. Lam will highlight the close and bi-directional relationships between epilepsy and AD, noting recent advances in our understanding of this topic spanning from animal models to humans. She will describe recent intracranial electrode recordings in humans that have revealed silent hippocampal epileptiform activity occurring in early stages of AD. Finally, she will discuss machine learning approaches that her laboratory has been developing to non-invasively diagnose and quantify silent hippocampal epileptiform activity from scalp EEG recordings.

PTK2B regulates electrical activity in human neurons and plays a role in the Aβ1-42-mediated neuronal hyperexcitability

Evidence of prodromal neuronal hyperexcitability and neuroinflammation in a rodent model of human alpha-synucleinopathy

FENS Forum 2024