neuronal vulnerability
Latest
Mechanisms of pathogenesis in the tauopathies
The distribution of pathological tau in the brain of patients with AD is highly predicable, and as disease worsens, it spreads transynaptically from initial regions of vulnerability. The reason why only some neurons are vulnerable to the accumulation and propagation of pathological forms of tau, and the mechanisms by which tauopathy spreads through the brain are not well understood. Using a combination of immunohistochemistry and computational analysis we have examined pathway differences between vulnerable and resistant neurons. How tau spreads across a synapse has been examined in vitro using different model systems. Our data show that dysregulation of tau homeostasis determines the cellular and regional vulnerability of specific neurons to tau pathology (H. Fu et al. 2019. Nat. Neuro. 22 (1):47-56) and that deficits in tau homeostasis can exacerbate tau accumulation and propagation. Aging appears to impact similar neuronal populations. Mechanisms and consequences of abnormal tau accumulation within neurons, its transfer between cells, pathology propagation and therapeutic opportunities will be discussed.
DISSECTING MICROGLIA-ASTROCYTE CROSSTALK AND CCL2-MEDIATED NEURONAL VULNERABILITY IN PARKINSON’S DISEASE USING IPSC-DERIVED MODELS
FENS Forum 2026
LOSS OF NEUROD2 EXACERBATES NEURONAL VULNERABILITY TO OXYGEN–GLUCOSE DEPRIVATION AND REPERFUSION
FENS Forum 2026
neuronal vulnerability coverage
3 items
Share your knowledge
Know something about neuronal vulnerability? Help the community by contributing seminars, talks, or research.
Contribute contentExplore how neuronal vulnerability research is advancing inside Neuroscience.
Visit domain