nicotine

Inter-individual variability in reward seeking and decision making: role of social life and consequence for vulnerability to nicotine

Inter-individual variability refers to differences in the expression of behaviors between members of a population. For instance, some individuals take greater risks, are more attracted to immediate gains or are more susceptible to drugs of abuse than others. To probe the neural bases of inter-individual variability  we study reward seeking and decision-making in mice, and dissect the specific role of dopamine in the modulation of these behaviors. Using a spatial version of the multi-armed bandit task, in which mice are faced with consecutive binary choices, we could link modifications of midbrain dopamine cell dynamics with modulation of exploratory behaviors, a major component of individual characteristics in mice. By analyzing mouse behaviors in semi-naturalistic environments, we then explored the role of social relationships in the shaping of dopamine activity and associated beahviors. I will present recent data from the laboratory suggesting that changes in the activity of dopaminergic networks link social influences with variations in the expression of non-social behaviors: by acting on the dopamine system, the social context may indeed affect the capacity of individuals to make decisions, as well as their vulnerability to drugs of abuse, in particular nicotine.

Neuroimmune and Glutamatergic Mechanisms of Nicotine Addiction

Role of the interneurons in prefrontal-based attentional dysfunctions in nicotine addiction

FENS Forum 2024

Adolescent nicotine exposure disrupts its anxiogenic properties in adulthood

Age-specific memory impairment induced by co-exposure to nicotine and a synthetic cannabinoid in mice

Chronic nicotine alters motivational value of natural rewards through circuit-based alterations in VTA dopamine neurons

Impact of the gut microbiota on nicotine effects and glia within the reward system in mice

The interpeduncular nucleus acts as a key modulator between reinforcement and aversive circuits in nicotine intake

Nicotine effects on anxiety behavior and brain biochemical markers in adult male mice and in rat hippocampal slices: patch clamp recordings

Phencyclidine and nicotine interactive effects in an adolescent mouse model of schizophrenia-like psychosis and nicotine misuse co-morbidity

Poor attentional control as a biomarker of vulnerability to nicotine addiction in male but not in female mice

Prenatal hypoxia related disturbances in glucocorticoid-dependent gene expression of chrna7 and genes of glutamate system are possible mechanism of development of nicotine addiction

Striatal cholinergic interneurons control nicotine withdrawal via muscarinic signaling

Unique gene expression profiles in the extinction of cocaine and nicotine self-administration

Exploring the neuroprotective effects of nicotine against MPTP-induced neuronal damage in mice: Insights into antioxidant system

FENS Forum 2024

Lavandula angustifolia or astrocytes alleviate nicotine plus high glucose-induced intracellular Ca2+ elevation in neurons and microglia

FENS Forum 2024

Nicotine biases motivational valence by altering brainstem cholinergic signals

FENS Forum 2024

Nicotine exposure during adolescence disrupts the dopaminergic circuitry in the ventral tegmental area

FENS Forum 2024

Nicotine suppresses feeding behavior by exerting opposite effects on the neuronal activity of the arcuate nucleus

FENS Forum 2024

Precise spatiotemporal photorelease of a systemically administered caged nicotine agonist in freely moving mice

FENS Forum 2024

Prenatal hypoxia, maternal stress, and the impact on CHRNA7 gene expression: Linking to nicotine addiction in adult offspring

FENS Forum 2024

Understanding the influence of the gut microbiome on the mesolimbic system and its response to nicotine

FENS Forum 2024

Understanding the neurobiological basis of the rewarding properties of flavored nicotine in e-cigarettes

FENS Forum 2024