oligodendrocyte progenitor cells

Modulation of oligodendrocyte development and myelination by voltage-gated Ca++ channels

The oligodendrocyte generates CNS myelin, which is essential for normal nervous system function. Thus, investigating the regulatory and signaling mechanisms that control its differentiation and the production of myelin is relevant to our understanding of brain development and of adult pathologies such as multiple sclerosis. We have recently established that the activity of voltage-gated Ca++ channels is crucial for the adequate migration, proliferation and maturation of oligodendrocyte progenitor cells (OPCs). Furthermore, we have found that voltage-gated Ca++ channels that function in synaptic communication between neurons also mediate synaptic signaling between neurons and OPCs. Thus, we hypothesize that voltage-gated Ca++ channels are central components of OPC-neuronal synapses and are the principal ion channels mediating activity-dependent myelination.

Injury-induced upregulation of fibronectin and BMP4 modulates the differentiation of oligodendrocyte progenitor cells into Schwann cells

"Milking": an innovative approach to investigate the properties of postnatal brain neural stem cells and to obtain oligodendrocyte progenitor cells from live experimental animals

Molecular and functional heterogeneity in dorsal and ventral oligodendrocyte progenitor cells of the mouse forebrain in response to DNA damage

Unraveling the roles of oligodendrocyte progenitor cells in the development of the cortical inhibitory system

FENS Forum 2024