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40 years of headache research
Lifelong devotion to headache research has led to many discoveries. First a series of studies of brain blood flow during attacks of migraine. The results showed changes compatible with cortical spreading depression in migraine without aura effectively negating the then prevailing vasospastic/ischemic theory. In migraine without aura no changes in brain blood flow. This difference was crucial for the separation of migraine with aura and migraine without aura in the first and subsequent editions of the international headache classification headed by me. Then a human migraine provocation model that has elucidated the molecular mechanisms of migraine. Successively we showed in series of papers the importance of nitric oxide, histamine, CGRP, PACAP and prostanoids. Therapeutic effectiveness of antagonizing these provokers by tonabersat, L-NMMA, CGRP receptor antagonists and monoclonal antibodies and of NSAIDs. Present and future attempts to put all these signaling mechanisms into a framework but it is not easy
Comparison of the effects of PACAP-38 and its analog on spatial memory
Immune regulation in GALT by immune checkpoint pathways in wild-type and PACAP-deficient mice
PACAP-VGLUT1 expressing subpopulation in hindbrain parabrachial complex forms synapse in extended amygdala: molecular and ultrastructural similarities and particularities comparing with Calyx-of-Held in brainstem auditory systems
A synthetic analogue of Pituitary Adenylate Cyclase-Activating Polypetide (PACAP) impoves motor and cognitive function in R6/1 mouse model of Huntington’s Disease
Comparative examination of the ventral tegmental area in wild type and pituitary adenylate cyclase-activating polypeptide (PACAP) knockout mice
FENS Forum 2024
PACAP at the crossroads: Interplay and synergy with other neuropeptides in headache disorders
FENS Forum 2024
A PACAP-glutamate-ACh pathway from a novel neuronal subpopulation in PB/KF innervates CeC PKCδ cells with calyceal terminal forming Gray I and II axosomatic synapses
FENS Forum 2024
PACAPergic brain projections to the ventral respiratory column
FENS Forum 2024
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