parvalbumin neurons

All optical interrogation of developing GABAergic circuits in vivo

The developmental journey of cortical interneurons encounters several activity-dependent milestones. During the early postnatal period in developing mice, GABAergic neurons are transient preferential recipients of thalamic inputs and undergo activity-dependent migration arrest, wiring and programmed cell-death. But cortical GABAergic neurons are also specified by very early developmental programs. For example, the earliest born GABAergic neurons develop into hub cells coordinating spontaneous activity in hippocampal slices. Despite their importance for the emergence of sensory experience, their role in coordinating network dynamics, and the role of activity in their integration into cortical networks, the collective in vivo dynamics of GABAergic neurons during the neonatal postnatal period remain unknown. Here, I will present data related to the coordinated activity between GABAergic cells of the mouse barrel cortex and hippocampus in non-anesthetized pups using the recent development of all optical methods to record and manipulate neuronal activity in vivo. I will show that the functional structure of developing GABAergic circuits is remarkably patterned, with segregated assemblies of prospective parvalbumin neurons and highly connected hub cells, both shaped by sensory-dependent processes.

Activation of basal forebrain parvalbumin neurons exerts frequency dependent effects on auditory processing and behavior in the rat

Continuous stress affects kainate receptor-dependent inhibition by parvalbumin neurons in the mouse amygdala

Attenuation of chondroitin 4 sulfate in the perineuronal nets of parvalbumin neurons leads to perseverance and increased social memory

FENS Forum 2024

Dlx5/6 involvement in the postnatal maturation of cortical parvalbumin neurons during critical periods

FENS Forum 2024