TopicNeuroscience

perfusion

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26Total items

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2Seminars

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SeminarNeuroscience

Adventures in Spin Labeling: Clinical Perfusion Imaging and the Path to Technical Innovation

Divya Bolar

University of California San Diego

Apr 24, 2026

Arterial spin labeling (ASL) MRI has become a vital tool in clinical neuroimaging, enabling noninvasive assessment of cerebral perfusion across a range of conditions including stroke, vascular malformations, and brain tumors. With broader clinical adoption, its practical strengths — as well as important limitations — have become increasingly clear.

SeminarNeuroscienceRecording

The wonders and complexities of brain microstructure: Enabling biomedical engineering studies combining imaging and models

Daniele Dini

Imperial College London

Nov 23, 2021

Brain microstructure plays a key role in driving the transport of drug molecules directly administered to the brain tissue as in Convection-Enhanced Delivery procedures. This study reports the first systematic attempt to characterize the cytoarchitecture of commissural, long association and projection fiber, namely: the corpus callosum, the fornix and the corona radiata. Ovine samples from three different subjects have been imaged using scanning electron microscope combined with focused ion beam milling. Particular focus has been given to the axons. For each tract, a 3D reconstruction of relatively large volumes (including a significant number of axons) has been performed. Namely, outer axonal ellipticity, outer axonal cross-sectional area and its relative perimeter have been measured. This study [1] provides useful insight into the fibrous organization of the tissue that can be described as composite material presenting elliptical tortuous tubular fibers, leading to a workflow to enable accurate simulations of drug delivery which include well-resolved microstructural features. As a demonstration of the use of these imaging and reconstruction techniques, our research analyses the hydraulic permeability of two white matter (WM) areas (corpus callosum and fornix) whose three-dimensional microstructure was reconstructed starting from the acquisition of the electron microscopy images. Considering that the white matter structure is mainly composed of elongated and parallel axons we computed the permeability along the parallel and perpendicular directions using computational fluid dynamics [2]. The results show a statistically significant difference between parallel and perpendicular permeability, with a ratio about 2 in both the white matter structures analysed, thus demonstrating their anisotropic behaviour. This is in line with the experimental results obtained using perfusion of brain matter [3]. Moreover, we find a significant difference between permeability in corpus callosum and fornix, which suggests that also the white matter heterogeneity should be considered when modelling drug transport in the brain. Our findings, that demonstrate and quantify the anisotropic and heterogeneous character of the white matter, represent a fundamental contribution not only for drug delivery modelling but also for shedding light on the interstitial transport mechanisms in the extracellular space. These and many other discoveries will be discussed during the talk." "1. https://www.researchsquare.com/article/rs-686577/v1, 2. https://www.pnas.org/content/118/36/e2105328118, 3. https://ieeexplore.ieee.org/abstract/document/9198110

perfusion

Latest

Adventures in Spin Labeling: Clinical Perfusion Imaging and the Path to Technical Innovation

The wonders and complexities of brain microstructure: Enabling biomedical engineering studies combining imaging and models

<EM >IN VIVO </EM>TWO-PHOTON IMAGING OF REPERFUSION INJURY IN A MOUSE MODEL OF ISCHEMIC STROKE

SYNTHETIC TORPOR IN THE RAT PROTECTS THE HEART FROM ISCHEMIA-REPERFUSION INJURY

ACTIVATING PROGESTERONE RECEPTOR IMPROVES VASCULAR PERFUSION AND REDUCES NEUTROPHIL AGGREGATION AFTER ISCHEMIC STROKE RECANALIZATION IN FEMALE AND AGED MICE

INTEGRATING COMPUTATIONAL AND EXPERIMENTAL APPROACHES TO REVEAL TAURINE’S MULTI-TARGET NEUROPROTECTION IN RETINAL ISCHEMIA/REPERFUSION INJURY

MODERATE VOLUME REDUCTION BUT REDUCED CONNECTIVITY AND ARTERIAL PERFUSION IN THE HIPPOCAMPUS IN LONG COVID

MECHANISMS OF HYPERTENSION-INDUCED NEUROVASCULAR DYSFUNCTION AND COGNITIVE IMPAIRMENT IN A MOUSE MODEL OF CHRONIC HYPOPERFUSION

CARBON MONOXIDE NANOMODULATOR REVERSES ISCHEMIA-REPERFUSION INJURY IN STROKE: A NOVEL DUAL-CHANNEL THERAPY MODE OF CO-DRIVING NEUROPROTECTION AND NEUROGENESIS

AN ACIDOSIS-SENSING PATHWAY IMPAIRS MICROGLIAL LYSOSOMAL FUNCTION TO DRIVE WHITE MATTER INJURY AND COGNITIVE DECLINE IN CHRONIC CEREBRAL HYPOPERFUSION

<EM>DICTYOTA</EM> SPP. DITERPENOIDS PROTECT MICROGLIA FROM ISCHEMIA-REPERFUSION INJURY BY MODULATING STRESS-RELATED PATHWAYS

ADIPONECTIN SIGNALING PRESERVES BLOOD–BRAIN BARRIER INTEGRITY AND COGNITIVE FUNCTION IN CHRONIC HYPOPERFUSION–INDUCED VASCULAR COGNITIVE IMPAIRMENT

PREVALENCE AND DETERMINANTS OF DIASCHISIS IN ACUTE UNILATERAL ANTERIOR CIRCULATION ISCHEMIC STROKE: A CT PERFUSION-BASED STUDY

LOSS OF NEUROD2 EXACERBATES NEURONAL VULNERABILITY TO OXYGEN–GLUCOSE DEPRIVATION AND REPERFUSION

TRANSCARDIAC PERFUSION IN MICE: COMPARING HEART-BEATING AND NON-BEATING CONDITIONS FOR BRAIN HISTOLOGICAL AND ELECTROPHYSIOLOGICAL ANALYSES

Cerebral hypoperfusion induced by carotid stenosis leads to hypoxia in oligodendrocyte precursor cells

Deep brain stimulation of the medial septum restores blood perfusion following pharmacologic NMDA antagonism in a region-dependent manner

Low-dose ionizing radiation as therapeutic intervention against chronic cerebral hypoperfusion-induced cognitive deficits

Mild hypothermia alleviates reductive stress, a root cause of ischemia reperfusion injury

Use of pCASL MRI sequence to study brain perfusion and vascular permeability after Blood Brain Barrier opening: limitations and perspectives

Assessment of metabolome in the tumor microenvironment by cerebral open flow microperfusion (cOFM) in a human glioblastoma xenograft animal model

Brain damage in APOE -/- mice with chronic cerebral hypoperfusion: participation of SIRT1, SIRT3 and IGF1

The default EEG reactivity to photic stimulation is impaired following global cerebral ischaemia and reperfusion

Impacts of ciproxifan on the tissue of the hippocampus in rats with cerebral ischemia-reperfusion

Neuroprotective effects of MK801 against cerebral ischemia-reperfusion injury

Progesterone alleviates neurological deficit and striatal ectonucleotidase activities after cerebral hypoperfusion in rats