peripheral inflammation

Associations between brain interoceptive network dysconnectivity and heightened peripheral inflammation in depression

Are the immune system, brain, mind and mood related? Could this explain why chronic low-grade peripheral inflammation is also noted in approximately 1/3 of those with major depressive disorder (MDD)? The field recognized today as immunopsychiatry was founded on scientific evidence that germinated over 30 years ago. Since, it has been understood that (i) there could be a causal link between inflammation and depression, (ii) select blood immune markers show robust potential as biomarkers for inflammation-linked depression, and more generally, (iii) Descartes' theories on mind-body dualism were biologically erroneous. Nonetheless, the mechanistic brain-immune axis in the trinity formulating inflammation-linked depression i.e. psycho-neuro-immunology, still remains unclear. This talk will discuss findings from our recent investigation endeavored to unpack this by linking functional connectivity abnormalities with peripheral immune markers.

Studying the effect of peripheral inflammation, specifically urinary tract infection, on neuroplasticity

The neurological consequences of peripheral inflammation: Delving into synaptic transmission and glial responses

FENS Forum 2024

Studying the effect of chronic peripheral inflammation, via transurethral instillation of LPS, on neuroplasticity

FENS Forum 2024