raphe nuclei

Organization of Midbrain Serotonin System

The serotonin system is the most frequently targeted neural system pharmacologically for treating psychiatric disorders, including depression and anxiety. Serotonin neurons of the dorsal and median raphe nuclei (DR, MR) collectively innervate the entire forebrain and midbrain, modulating diverse physiology and behaviour. By using viral-genetic methods, we found that DR serotonin system contains parallel sub-systems that differ in input and output connectivity, physiological response properties, and behavioural functions. To gain a fundamental understanding of the molecular heterogeneity of DR and MR, we used single-cell RNA - sequencing (scRNA-seq) to generate a comprehensive dataset comprising eleven transcriptomically distinct serotonin neuron clusters. We generated novel intersectional viral-genetic tools to access specific subpopulations. Whole-brain axonal projection mapping revealed that the molecular features of these distinct serotonin groups reflect their anatomical organization and provide tools for future exploration of the full projection map of molecularly defined serotonin groups. The molecular architecture of serotonin system lays the foundation for integrating anatomical, neurochemical, physiological, and behavioural functions.

Interactions between the Edinger-Westphal and Dorsal Raphe Nuclei promote parental nesting

Age-dependent dynamics in acute and chronic stress-induced FOSB/∆FOSB content in the extended amygdala, hypothalamic paraventricular, habenular, centrally-projecting Edinger-Westphal and dorsal raphe nuclei in male rats

The role of MicroRNA-34a on Dorsal Raphe Nuclei neurotransmission in response to specific valence stimuli

Dorsal raphe nuclei/ventrolateral periaqueductal grey and cerebellar fastigial nucleus interactions modulate danger response during fear learning

FENS Forum 2024

The effects of CRF agonists and antagonists on the noradrenaline released from the locus coeruleus and the serotonin released from the raphe nuclei

FENS Forum 2024

Mapping the neural circuitry: LC-NE neurons and their connections to VTA and Raphe nuclei

FENS Forum 2024