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Functional segregation of rostral and caudal hippocampus in associative memory
It has long been established that the hippocampus plays a crucial role for episodic memory. As opposed to the modular approach, now it is generally assumed that being a complex structure, the HC performs multiplex interconnected functions, whose hierarchical organization provides basis for the higher cognitive functions such as semantics-based encoding and retrieval. However, the «where, when and how» properties of distinct memory aspects within and outside the HC are still under debate. Here we used a visual associative memory task as a probe to test the hypothesis about the differential involvement of the rostral and caudal portions of the human hippocampus in memory encoding, recognition and associative recall. In epilepsy patients implanted with stereo-EEG, we show that at retrieval the rostral HC is selectively active for recognition memory, whereas the caudal HC is selectively active for the associative memory. Low frequency desynchronization and high frequency synchronization characterize the temporal dynamic in encoding and retrieval. Therefore, we describe here anatomical segregation in the hippocampal contributions to associative and recognition memory.
MOLECULAR CHOREOGRAPHY OF TEMPORAL MEMORY: PREFRONTAL ERK1/2 SIGNALING REGULATES RECOGNITION MEMORY STABILITY IN MICE
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