saturated fatty acids

Western diet consumption and memory impairment: what, when, and how?

Habitual consumption of a “Western diet”, containing higher than recommended levels of simple sugars and saturated fatty acids, is associated with cognitive impairments in humans and in various experimental animal models. Emerging findings reveal that the specific mnemonic processes that are disrupted by Western diet consumption are those that rely on the hippocampus, a brain region classically linked with memory control and more recently with the higher-order control of food intake. Our laboratory has established rat models in which excessive consumption of different components of a Western diet during the juvenile and adolescent periods of development yields long-term impairments in hippocampal-dependent memory function without concomitant increases in total caloric intake, body weight, or adiposity. Our ongoing work is investigating alterations in the gut microbiome as a potential underlying neurobiological mechanism linking early life unhealthy dietary factors to adverse neurocognitive outcomes.

Effects of dietary supplementation with deuterated polyunsaturated fatty acids in experimental traumatic brain injury

FENS Forum 2024

Post-translational modifications of tau protein in neuronal cells exposed to saturated fatty acids: implications for Alzheimer´s disease

Lasting effects of early dietary intervention with different ω6/ω3 polyunsaturated fatty acids ratios in an animal model of Alzheimer’s disease

FENS Forum 2024