TopicNeuroscience

social defeat

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SeminarNeuroscience

Decoding stress vulnerability

Stamatina Tzanoulinou

University of Lausanne, Faculty of Biology and Medicine, Department of Biomedical Sciences

Feb 20, 2026

Although stress can be considered as an ongoing process that helps an organism to cope with present and future challenges, when it is too intense or uncontrollable, it can lead to adverse consequences for physical and mental health. Social stress specifically, is a highly prevalent traumatic experience, present in multiple contexts, such as war, bullying and interpersonal violence, and it has been linked with increased risk for major depression and anxiety disorders. Nevertheless, not all individuals exposed to strong stressful events develop psychopathology, with the mechanisms of resilience and vulnerability being still under investigation. During this talk, I will identify key gaps in our knowledge about stress vulnerability and I will present our recent data from our contextual fear learning protocol based on social defeat stress in mice.

social defeat

Latest

Decoding stress vulnerability

HETEROGENEOUS MICROGLIAL REMODELING IN AMYGDALA AND HABENULA UNDER DIVERSE STRESS PARADIGMS: ACUTE, CHRONIC, AND SOCIAL DEFEAT STRESS

CHARACTERIZING BEHAVIORAL CHANGES FOLLOWING ACUTE AND CHRONIC SOCIAL DEFEAT STRESS IN MALE AND FEMALE MICE: SEX-SPECIFIC MANIFESTATIONS OF RESILIENCE AND SUSCEPTIBILITY

CLAUSTRUM ENSEMBLES MEDIATE SOCIAL DEFEAT STRESS-INDUCED HYPERVIGILANCE

CARDIAC PREDICTORS OF STRESS SUSCEPTIBILITY: LONGITUDINAL EVIDENCE FROM THE CHRONIC SOCIAL DEFEAT MODEL

INFLUENCE OF REPEATED SOCIAL DEFEAT STRESS IN THE NEURAL ACTIVITY OF THE SPINAL DORSAL HORN OF MICE

FROM EARLY LIFE STRESS TO ADULT OUTCOMES: A JUVENILE SOCIAL DEFEAT MODEL IN MICE

HYPERACTIVE GSK3 SIGNALING FAILS TO PRESERVE MPFC NEURONAL EXCITABILITY IN MICE SUSCEPTIBLE TO CHRONIC SOCIAL DEFEAT STRESS

RE-GROUPING AFTER SOCIAL STRESS : EVALUATING THE EFFECT OF SOCIAL DEFEAT STRESS ON ALLOGROOMING AND HOMECAGE INTERACTIONS IN MICE​

SEX-SPECIFIC EFFECTS OF CHRONIC NON-DISCRIMINATORY SOCIAL DEFEAT STRESS (CNSDS) ON VENTRAL HIPPOCAMPAL PLASTICITY AND BEHAVIORAL VULNERABILITY

Role of immediate early genes in neural plasticity during social defeat

Social defeat during adolescence increases the susceptibility to an immune challenge later in life

Social defeat stress induces microglial alterations and impaired cell survival in the hypothalamus according to behavioral phenotype

The analyses of neural basis for individual differences in behavioral outcomes caused by long-term social defeat stress in mice

Newly Formed Synapses Between VTA Projections and ACC Pyramidal Neurons in Response to Chronic Social Defeat Stress Differentiate Stress Susceptible From Stress Resilient Mice

Female microglia and neurogenesis respond differently to social defeat stress compared to males

Intermittent access to a high-fat diet blocks the increase in ethanol consumption and the neuroinflammatory response induced by social defeat in adult male mice

Ketogenic diet buffers brain gene expression and ethanol consumption induced by vicarious social defeat exposure in female mice

Raphe nucleus function in aversive valence processing between adaptive learning and social defeat in zebrafish

Role of the medial amygdala glutamatergic and GABAergic neurons during social defeat

TPH2 knockout rats cannot accept social defeat in resident-intruder test

Brain-wide scale neuronal activation of behavioral outcomes following learned helplessness and acute social defeat stress in mice

Anxiety levels after vicarious social defeat stress are associated with vulnerability and resilience to cocaine-induced conditioned place preference in female mice

Automatically annotated motion tracking identifies a distinct social behavioral profile following chronic social defeat stress

Brain stress and noradrenergic system mediate the mechanisms underlying relapse caused by exposure to Social Defeat in the nucleus accumbens in morphine dependent mice

Does physical exercise offer resilience in a social defeat stress mouse model?

Effects of chronic stress on hippocampal microglia and neurogenesis of mice under social defeat stress

H3K4me3 epigenetic signatures in social defeat stress of varying duration

Meta-analysis of prefrontal cortex RNA-seq data after social defeat stress of varying duration

Mir-34 family is involved in Chronic Social Defeat-induced vulnerability to mood disorders and cardiac mitochondrial dysfunctions

RE-GROUPING AFTER SOCIAL STRESS : EVALUATING THE EFFECT OF SOCIAL DEFEAT STRESS ON ALLOGROOMING AND HOMECAGE INTERACTIONS IN MICE