sympathetic

Clonal analysis at single cell level helps to understand neural crest development

Recent research on the neural crest has revealed the multipotency and plasticity of nerve-associated Schwann cell precursors, which can differentiate into diverse cell types, including parasympathetic neurons, neuroendocrine cells, and mesenchymal stem cells. These findings challenge the traditional view of peripheral nerves, highlighting their role as niches for migratory progenitor cells that contribute to tissue formation and regeneration.

Sympathetic nerve remodeling in adipose tissue

Sympathetic nerve activation of adrenergic receptors on fat is the major pathway the brain uses to drive non-shivering thermogenesis in brown adipose tissue and lipolysis in white fat. There is accumulating evidence that the peripheral nerve architecture inside of organs is plastic (can be remodeled) but the factors and conditions that regulate or result in remodeling are largely unknown. Particularly for fat, it remains unclear if nerves in fat can be remodeled in step with hyperplasia/trophy of adipose tissue as result of a prolonged energy surfeit. This talk will discuss our recent work identifying the sympathetic nerve architecture in adipose tissue as highly plastic in response to the adipose hormone leptin, the brain circuitry leptin acts on to regulate this and the physiological effects remodeling of innervation has on fat tissue function.

Sympathetic control of lymph node function

Peripheral nerve injury can cause debilitating disease and immune-cell mediated destruction of the affected nerve. While the focus of most studies has been on the nerve-degenerative response, the effect of loss of innervation on lymph node function is largely unclear. Here, I will discuss the cellular and molecular events caused by local denervation and loss of direct neural input to the popliteal lymph node that induce an inflammatory response and lymph node expansion.

Untitled Seminar

Sympathetic Associated Perineurial Cells (SAPCs) orchestrate neuroendocrine loop of leptin action to maintain metabolic homeostasis

Sympathetic axonal sprouting induces changes in macrophage populations and protects against pancreatic cancer

Functional characterization of human induced pluripotent stem cell-derived sympathetic neurons

FENS Forum 2024

Psychological stress regulation of acute-phase proteins through the hepatic sympathetic innervation

FENS Forum 2024

Sympathetic neural-immune interactions involved in early life stress-induced gastrointestinal disorder

FENS Forum 2024