synaptic adhesion

Nature, nurture and synaptic adhesion in between

Exposure to proper environment during early development is essential for brain maturation. Impaired sensory input or abnormal experiences can have long-term negative consequences on brain health. We seek to define the precise synaptic aberrations caused by abnormal visual experiences early in life, and how these can be remedied through viral, genetic and environmental approaches. Resulting knowledge will contribute to the development of new approaches to mitigate nervous system damage caused by abnormal early life experience.

Two autism-related mouse models – differences in the hypothalamic gene expression of synaptic adhesion molecules and inhibitory neurotransmitter markers

GABAA receptors and neuroligin 2 synergize to promote synaptic adhesion and inhibitory synaptogenesis

FENS Forum 2024