tau phosphorylation
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Unique Molecular Regulation of Prefrontal Cortex Confers Vulnerability to Cognitive Disorders
The Arnsten lab studies molecular influences on the higher cognitive circuits of the dorsolateral prefrontal cortex (dlPFC), in order to understand mechanisms affecting working memory at the cellular and behavioral levels, with the overarching aim of identifying the actions that render the dlPFC so vulnerable in cognitive disorders. Her lab has shown that the dlPFC has unique neurotransmission and neuromodulation compared to the classic actions found in the primary visual cortex, including mechanisms to rapidly weaken PFC connections during uncontrollable stress. Reduced regulation of these stress pathways due to genetic or environmental insults contributes to dlPFC dysfunction in cognitive disorders, including calcium dysregulation and tau phosphorylation in the aging association cortex. Understanding these unique mechanisms has led to the development of a new treatment, IntunivTM, for a variety of PFC disorders.
Prediabetes and type 2 diabetes affect tau phosphorylation patterns in murine models of Alzheimer’s disease
FENS Forum 2024
Type one diabetes modifies tau phosphorylation patterns and worsens cognitive impairment in the APP/PS1 mouse model of Alzheimer’s disease
FENS Forum 2024
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