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SeminarNeuroscience

Spontaneous activity competes with externally evoked responses in sensory cortex

Golan Karvat
Diester lab, University of Freiburg, Germany
Nov 25, 2021

The interaction between spontaneously and externally evoked neuronal activity is fundamental for a functional brain. Increasing evidence suggests that bursts of high-power oscillations in the 15-30 Hz beta-band represent activation of resting state networks and can mask perception of external cues. Yet demonstration of the effect of beta power modulation on perception in real-time is missing, and little is known about the underlying mechanism. In this talk I will present the methods we developed to fill this gap together with our recent results. We used a closed-loop stimulus-intensity adjustment system based on online burst-occupancy analyses in rats involved in a forepaw vibrotactile detection task. We found that the masking influence of burst-occupancy on perception can be counterbalanced in real-time by adjusting the vibration amplitude. Offline analysis of firing-rates and local field potentials across cortical layers and frequency bands confirmed that beta-power in the somatosensory cortex anticorrelated with sensory evoked responses. Mechanistically, bursts in all bands were accompanied by transient synchronization of cell assemblies, but only beta-bursts were followed by a reduction of firing-rate. Our closed loop approach reveals that spontaneous beta-bursts reflect a dynamic state that competes with external stimuli.

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