Poster preview
ePoster
ALTERED CORTEX-WIDE DYNAMICS DISRUPT MOTOR PLANNING IN SHANK3-MUTANT MICE
Manuel Ambrosoneand 5 co-authors
LENS
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS04-08PM-279
Presentation
Date TBA
Board: PS04-08PM-279
Event Information
Poster Board
PS04-08PM-279
Poster
View posterAbstract
Coordinated activity across the cortex is essential for voluntary movement planning, and disruptions to this process have been linked to neurodevelopmental disorders such as autism spectrum disorder (ASD). Mutations in the SHANK3 gene, a major genetic risk factor for ASD, are known to alter synaptic structure and cortical network organization, yet their effects on preparatory cortical activity remain poorly understood. In this study, we combined wide-field calcium imaging, behavioral tracking, and computational motif analysis to investigate cortex-wide dynamics in Shank3b⁺/⁻ mice during spontaneous forepaw movements. We observed a weakened relationship between cortical activity and behavior prior to movement initiation, along with reduced expression of specific cortical motifs spanning associative and motor regions. These alterations were associated with widespread functional hyperconnectivity and deficits in motor planning. Together, our results demonstrate that disrupted spatiotemporal cortical dynamics in Shank3b⁺/⁻ mice compromise preparatory motor processes, offering mechanistic insight into motor impairments associated with ASD.
Recommended posters
ALTERED CORTEX-WIDE SPONTANEOUS DYNAMICS ACCOMPANY ENHANCED SENSORY RESPONSE AMPLITUDE AND VARIABILITY IN SHANK3B MICE
Zijia Yu, Yonglie Ma, Ryan Zahacy, Ian Winship, Allen Chan
EARLY DEVELOPMENTAL STRUCTURAL AND FUNCTIONAL ALTERATIONS IN HIPPOCAMPAL CA1 IN SHANK3 MUTANT MICE
Mirindra Ratsifandrihamanana, Marat Minlebaev, Arthur Godino, Carmen San Martin Segovia, Robin F. Dard, Marie Giorgi-Kurz, Agnès Baude, Emmanuel Daucé, Rosa Cossart, Michel A. Picardo
DISRUPTED THALAMIC ENCODING OF TACTILE PROCESSING IN JUVENILE SHANK3B MUTANT MICE
Regina Andrea Mejia-Ortiz, Mario G. Martinez-Montalvo, Perla Gonzalez-Pereyra, Marcela Palomero-Rivero, Pavel Ernesto Rueda-Orozco, Violeta Gisselle Lopez-Huerta
DISSECTING STATE-DEPENDENT VISUAL THALAMOCORTICAL DYNAMICS IN A MOUSE MODEL OF ASD
Liya Niv, Matthias Eder, Dennis B. Nestvogel
THALAMOCORTICAL ENCODING OF TACTILE STIMULI IN THE SHANK3 KO MOUSE MODEL OF AUTISM SPECTRUM DISORDER
Margarida Falcão, Patrícia Monteiro, Luís Jacinto
GENE X ENVIRONMENT INTERACTION IN A NEURONAL MODEL OF SHANK3-RELATED AUTISM SPECTRUM DISORDER
Federica Polverini, Lorenzo Curti, Valentina Scianaro, Miriam Cerullo, Jessica Mingardi, Noemi Nicosia, Laura Musazzi, Alessio Masi, Guido Mannaioni