Transplanted human brain-tissue takes root in mice without a cortex

Benjamin Thompson, Nick Petrić Howe
Published Sep 16, 2026

Description

This Nature Podcast episode examines human brain organoids transplanted into mice lacking a cerebral cortex, where extensive cellular integration could create an in-vivo platform for testing therapies and studying human neurobiology. It also covers research highlights and Paper2Agent, an AI system that turns research papers into interactive virtual corresponding authors able to answer questions and support complex scientific tasks.

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