Interneuron desynchronization and breakdown of long-term place cell stability in temporal lobe epilepsy
Schedule
Wednesday, August 5, 2020
16:00 UTC
Peyman Golshani
Prof
UCLA
Host: Clinical and Experimental Epilepsy
Recording
Open recording
Event Information
Recording
Available
Host
Clinical and Experimental Epilepsy
Duration
70 minutes
Abstract
Temporal lobe epilepsy is associated with memory deficits but the circuit mechanisms underlying these cognitive disabilities are not understood. We used electrophysiological recordings, open-source wire-free miniaturized microscopy and computational modeling to probe these deficits in a model of temporal lobe epilepsy. We find desynchronization of dentate gyrus interneurons with CA1 interneurons during theta oscillations and a loss of precision and stability of place fields. We also find that emergence of place cell dysfunction is delayed, providing a potential temporal window for treatments. Computation modeling shows that desynchronization rather than interneuron cell loss can drive place cell dysfunction. Future studies will uncover cell types driving these changes and transcriptional changes that may be driving dysfunction.
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