Manipulating single-unit theta phase-locking with PhaSER: An open-source tool for real-time phase estimation and manipulation
Schedule
Tuesday, May 9, 2023
04:00 UTC
Zoe Christenson-Wick
Mount Sinai School of Medicine, NY, USA
Host: Cambridge NeuroTech
Recording
Open recording
Event Information
Recording
Available
Host
Cambridge NeuroTech
Duration
70 minutes
Abstract
Zoe has developed an open-source tool PhaSER, which allows her to perform real-time oscillatory phase estimation and apply optogenetic manipulations at precise phases of hippocampal theta during high-density electrophysiological recordings in head-fixed mice while they navigate a virtual environment. The precise timing of single-unit spiking relative to network-wide oscillations (i.e., phase locking) has long been thought to maintain excitatory-inhibitory homeostasis and coordinate cognitive processes, but due to intense experimental demands, the causal influence of this phenomenon has never been determined. Thus, we developed PhaSER (Phase-locked Stimulation to Endogenous Rhythms), a tool which allows the user to explore the temporal relationship between single-unit spiking and ongoing oscillatory activity.
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