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Prof
Newcastle University
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Schedule
Wednesday, September 2, 2020
5:00 PM Europe/London
Domain
NeuroscienceHost
Clinical and Experimental Epilepsy
Duration
70 minutes
Seizure onset is a critically important brain state transition that has proved very difficult to predict accurately from recordings of brain activity. I will present new data acquired using a range of optogenetic and imaging tools to characterize exactly how cortical networks change in the build-up to a seizure. I will show how intermittent optogenetic stimulation ("active probing") reveals a latent change in dendritic excitability that is tightly correlated to the onset of seizure activity. This data relates back to old work from the 1980s suggesting a critical role in epileptic pathophysiology for dendritic plateau potentials. Our data show how the precipitous nature of the transition can be understood in terms of multiple, synergistic positive feedback mechanisms.
Andrew Trevelyan
Prof
Newcastle University
neuro
neuro
In this talk, I will discuss the OpenNeuro Fitlins GLM package and provide an illustration of the analytic workflow. OpenNeuro FitLins GLM is a semi-automated pipeline that reduces barriers to analyzi
neuro
Applications are invited for our third edition of Systems Vision Science (SVS) summer school since 2023, designed for everyone interested in gaining a systems level understanding of biological vision.