Seminars

Kuan Hong Wang examines how dopaminergic, cannabinoid, and neuroimmune signaling regulate circuit plasticity across development, experience, and disease, and how cross-species work may inform selective therapies.

Interpreting human missense variants requires connecting genomic coordinates with protein sequences, structures and functional evidence. ProtVar integrates annotations and predictions from UniProt, Ensembl, PDBe, Open Targets and AlphaFoldDB, extending variant lookup to discovery across more than 500 million potential missense variants. This seminar demonstrates natural-language searches using diseases, pathways and drug responses, multi-criteria filtering, structural visualisation and data export. Participants will learn to prioritise variants, interpret their structural and functional effects, and retrieve data through web downloads or the REST API. The session serves geneticists, drug-discovery researchers and computational biologists; undergraduate molecular biology and genetics are recommended.

John N. Constantino and Jeffrey Borenstein examine how individualized education planning can support children with developmental, behavioral and mental-health challenges. Educators and counselors often recognize difficulties early, and the extensive time children spend at school offers a major opportunity to support maturation alongside clinical care. The discussion explores the complexities of individualized education plans and how educators and clinicians can apply precision-medicine approaches to tailor them to each child, making everyday school experiences more effective for development and adaptation.