Single-cell transcriptomic profiles of the ventral hippocampus in response to prolonged chronic stress and antidepressant action
Benedetta Bigio, Shofiul Azam, Neelu John, Yotam Sagi, Chaitan Khosla, Carla Nasca · FENS Forum 2024
The dentate gyrus (DG) of the ventral hippocampus is a key hub critical for the responses to prolonged chronic stress and antidepressant drugs, including the antidepressant candidate acetyl-L-carnitine (LAC). Prior studies from our and other laboratories showed transcriptome-wide signatures in this brain area with robust changes in genes important for neuronal plasticity, including the metabotropic glutamate receptor-2 (mGlu2), and insulin signaling pathways after chronic stress, and that these changes are ameliorated by short-term administration of LAC. Here, we used 10X Genomics droplet-base
ePoster · Neuroscience