Mitigation of pathological tau abnormalities by the natural antioxidant uric acid: Comparison with DOT, a non-antibiotic oxytetracycline derivative
Bianca Andretto de Mattos, Rodrigo Hernán Tomas Grau, Florencia González-Lizárraga, Thais Alves Fernandes, Aurore Tourville, Ismaila Ciss, Jean-Michel Brunel, Annie Lannuzel, Laurent Ferrié, Rosana Chehin, Rita Raisman-Vozari, Bruno Figadère, Elaine Del-Bel, Patrick Pierre Michel · FENS Forum 2024
We aimed to model tau abnormalities in the early and advanced stages of Alzheimer’s disease and other tauopathies. By doing so, we wanted to evaluate molecules capable of preventing tau-mediated neurodegeneration. To achieve this, we established cultures of mouse cortical neurons in which hyperphosphorylated (but not aggregated) tau accumulates in a significant population of neurons following chronic exposure to redox-active iron from hemin (Hm), a breakdown product of hemoglobin. Using experimental conditions in which p-tau (AT8 immunosignal) accumulation occurs without concomitant neuronal l
ePoster · Neuroscience