APOE genotype effects on the human gut microbiome
Ioanna Freri, David Berry, Isabella C. Wagner · FENS Forum 2024
Alzheimer’s disease (AD) is the most common form of dementia. Its strongest genetic risk factor is the e4 allele of the apolipoprotein E (APOE), and risk scales with APOE-e4 load (e4/e4 > e4/e3 > e3/e3). APOE-e4 has been linked to distinct gut microbiome composition in murine models, but genotype effects on the human gut microbiome remain unclear. Here, we hypothesized differential gut microbiome composition in healthy, younger adults (20-35 years) with genetic AD risk (i.e., individuals carrying one copy of the APOE-e4 allele, APOE-e4/e3) compared to controls (i.e., APOE-e3/e3). We geno
ePoster · Neuroscience