Topic: 2-hit mouse model

Schizophrenia (SCZ) is a frequent psychosis related to combination between genetic and environmental factors. To advance current treatments, it is important to improve animal models by considering its multifactorial etiology. Our study aimed to characterize an innovative 2-hit mouse model combining the deletion of serine racemase (genetic factor) associated with a maternal separation for 24h at post-natal day 9 (early stressing environmental factor), which both have been previously suggested to possibly drive SCZ-like symptoms. The face facility of this 2-hit model was assessed through behavio