Noradrenergic α2 receptor: A promising central target for urolithins
Veronica Torre, Guendalina Olivero, Alice Taddeucci, Nicole Rosenwasser, Federica Turrini, Raffaella Boggia, Anna Pittaluga · FENS Forum 2024
Ellagic acid (EA) is a polyphenol that contributes to the nutraceutical properties of pomegranate. In the brain it was reported to control noradrenaline release. Recently, we demonstrated that EA binds α2 receptors (α2R), mimicking the full-agonist clonidine. The study was extended to Urolithins (URO) A, B and C which represent the main metabolites of EA in mammals, following a chronic (14 days) administration of an EA micro-formulation (EAm).“In vitro” studies were carried out on cortical and hippocampal synaptosomes isolated from control mice acutely exposed to the UROs, clonidine and yohimb
ePoster · Neuroscience