GABAA receptors and neuroligin 2 synergize to promote synaptic adhesion and inhibitory synaptogenesis
Yusheng Sui, Martin Mortensen, Martin Nicholson, Trevor Smart, Jasmina Jovanovic · FENS Forum 2024
GABAA receptors (γ-aminobutyric acid-gated receptors type A) are the essential structural and functional postsynaptic components of inhibitory synapses in the mammalian brain. They belong to a family of GABA-gated Cl/HCO3-permeable ion channels which are built as hetero-pentamers of subunits classified as α(1-6), β(1-3), γ(1-3), δ, ε, π, θ and ρ(1-3). How, where, and when the inhibitory synapses are formed is tightly regulated during early brain development and later synaptogenesis by genetic and environmental factors. Multiple proteins have been shown to participate in the initiation and func
ePoster · Neuroscience