Topic: 22q11.2 microdeletion

Sleep deficits are often prodromal to the onset of psychiatric diseases. Such disorders, for example schizophrenia, autism spectrum disorder or attention deficit hyperactivity disorder, are strongly linked to the 22q11.2 microdeletion (22qdel). Carriers of 22qdel exhibit reduced sleep spindle formation, which correlates to decreased memory performance and disease severity. Two neurological cell populations, the noradrenergic (NA) neurons in the locus coeruleus (LC) and the parvalbumin (PV)-positive cortical interneurons are involved in the regulation of sleep spindles. However, the interplay o