Topic: 22q11 microdeletion

Schizophrenia is a major disabling psychiatric disease, significantly impacts patients' social functioning. The lateral septum (LS), a brain region connecting the cortex to the hypothalamus and crucial for regulating affect and social behaviors, is implicated in schizophrenia. We hypothesized that specific populations of LS neurons regulating social interactions are dysregulated during schizophrenia and leveraged the Df(16)A+/- mouse model of schizophrenia to test our hypothesis. This model contains the human 22q11 microdeletion, which in humans, confers a 30% probability to develop schizophre