A deep-learning approach to quasi-instantaneous Markov modeling of ion channel gating
Efthymios Oikonomou, Rajkumar Kolan, Linda Kern, Thomas Gruber, Christian Alzheimer, Patrick Krauss, Andreas Maier, Tobias Huth · FENS Forum 2024
The patch-clamp technique allows us to eavesdrop the gating behavior of individual ion channels with unprecedented temporal resolution. The recorded signals arise from conformational changes of the protein or protein complex forming the ion channels as they make rapid transitions between conducting and non-conducting states. However, unambiguous analysis of single-channel datasets is challenging given the inadvertently low signal-to-noise ratio as well as signal distortions caused by low-pass filtering and limited recording bandwidth. Ion channel kinetics are typically described using hidden-M
ePoster · Neuroscience