Functional analysis of spontaneous neuronal activity in cortical organoids as a model of human tauopathies
Karolina Zimkowska, Marc Riu-Villanueva, Amayra Hernández-Vega, Pol Picón-Pagès, Irene Fernandez-Carasa, Jorge Oliver-De La Cruz, Pere Roca-Cusachs, Antonella Consiglio, José Antonio del Río · FENS Forum 2024
Spontaneous neuronal activity (SNA) plays an important role in the maturation and refinement of neuronal connections. However, neurodegenerative diseases, like tauopathies, can significantly alter SNA. Changes in SNA after the expression of tau mutations have not yet been analysed at presymptomatic stages. Furthermore, the currently available models lack the necessary complexity of the human brain to fully understand the underlying mechanisms of tau pathology and its effects on SNA. To address this, we present a novel in vitro platform utilizing cortical organoids (COs), derived from hPSCs, to
ePoster · Neuroscience