Topic: 3-hit mouse model

Cognitive deficits and negative symptoms associated with schizophrenia are poorly managed by current antipsychotics. In order to develop effective treatments, refining animal models of schizophrenia is essential. To address its multifactorial etiology, we developed a new 3-hit mouse model. This model was mostly concealing the glutamatergic deficit hypothesis of the pathology (underlying cognitive and negative deficits). Thus, a genetic susceptibility (serine racemase deletion) was associated to environmental stress (24h maternal separation at 9-day of age) and pharmacological treatment (phency