ePoster · Computational Neuroscience
Investigating hippocampal synaptic plasticity in Schizophrenia: a computational and experimental approach using MEA recordings
Sarah Hamdi Cherif, Candice Roux, Valentine Bouet, Jean-Marie Billard, Jérémie Gaidamour, Laure Buhry, Radu Ranta · Bernstein Conference 2024
Among the brain structures affected in Schizophrenia is the hippocampus. In addition to structural changes [1], dysfunctions of the synaptic plasticity have also been observed supporting cognitive impairment [2]. To study these phenomena in depth, we aim to develop and match two models of the pathology, computational and experimental. Our work is based on an existing computational hippocampus model [3] and a 3-hits mouse model [4]. For that purpose, we analyze electrophysiological signals recorded with Multi-Electrode Array (MEA) on hippocampal slices to extract synaptic transmission character