Lifelong exposure to high fat diet leads to depressive-like phenotype associated with increased central amyloid oligomer formation
Maria Grazia Morgese, Lisa Pia Agosti, Maria Adelaide Palmieri, Luigia Trabace · FENS Forum 2024
Obesity and excessive consumption of saturated fats represent important predisposing factors to the development of neurodegenerative disorders such as Alzheimer's disease (AD) and its neuropsychiatric comorbidities. Alteration of amyloid β (Aβ) homeostasis is considered the main neuropathological feature of AD and increased levels of the oligomeric forms of this peptide have been associated with increased risk of depressive states. The exposure to obesogenic environment, such as high fat diet (HFD), seems to impair Aβ catabolic function leading to the production of its neurotoxic species. In t
ePoster · Neuroscience