The function of perineuronal nets, integrins, and neuroligin-2 in input-specific GABAergic long-term plasticity
Wiera Grzegorz, Jadwiga Jablonska, Anna Lech, Jerzy Mozrzymas · FENS Forum 2024
Although diverse stimulation patterns induce excitatory plasticity, they concurrently trigger long-term potentiation (iLTP) or depression (iLTD) at inhibitory synapses. Nevertheless, the precise plasticity rules and molecular mechanisms governing the interaction between excitatory and GABAergic plasticity remain unclear. Here, we aimed to elucidate these mechanisms in slices by simultaneously recording excitatory and distinct optogenetically evoked inhibitory postsynaptic currents in hippocampal CA1 pyramidal cells (CA1PCs). Long-term plasticity was induced by NMDA treatment.Our experiments re
ePoster · Neuroscience