Topic: 3’ untranslated regions (3’UTRs)

Gene expression is heavily controlled at the level of mRNA translation into protein, allowing for stimulus-dependent and compartment-specific activation of protein synthesis. In neurons, mRNA transport to dendrites and axons and local translation are crucial for development, repair, synaptic function and memory formation.3’ untranslated regions (3’UTRs) are known for regulation of RNA localization, stability and translation. Past research identified many of the molecular mechanisms and players involved, but we still lack a systematic understanding of how the regulatory information is encoded i