Impaired subcellular localization of synaptic mRNAs underlies connectivity deficits in schizophrenia
Alessia Atella, Valéria de Almeida, Miriam Gagliardi, Anna Hausruckinger, Florian Raabe, Marie Dawczynski, Georgii Dolgalev, Moritz J. Rossner, Sabrina Galinski, Volker Scheuss, Michael Ziller · FENS Forum 2024
Many studies have demonstrated a role for alternative polyadenylation (APA) of the 3'UTR region in the subcellular localization of mRNA in neurons, but to date, there has been little evidence of a link to psychiatric disorders, particularly schizophrenia.However, our group has recently demonstrated an alteration of polyadenylation in a large cohort of iPSC-derived cortical glutamatergic neurons from healthy controls and schizophrenic (SCZ) patients as well as from post-mortem brains.104 iPSCs-derived cortical glutamatergic neurons were characterized by RNA-Seq, revealing that the use of the ca
ePoster · Neuroscience