Topic: 3D anatomical information

Dendrites perform non-linear processing of synaptic inputs, and drive active processes such as plateau potentials which are critical to computation and plasticity. Therefore, the ability to image voltage across an entire dendritic tree would represent a major advance in systems neuroscience. Recent advances in genetically encoded voltage indicators (GEVIs) have brought this possibility closer to reality. However, due to the fundamental tradeoff between imaging speed and volume, it has been impossible thus far to image an entire dendritic tree using volumetric imaging at high speeds. To get aro