Epigenetic mechanisms of information storage in the onset of drug addiction
Luna Zea Redondo, Vedran Franke, Christoph Thieme, Warren Winick-Ng, Eleanor J. Paul, Laura Arguedas, Ibai Irastorza-Azcarate, Alexander Kukalev, Oscar Marin, Altuna Akalin, Mark A. Ungless · FENS Forum 2024
Dopaminergic neurons (DNs) from the Ventral Tegmental Area (VTA) are associated with addiction and are the first neurons to respond to a single dose of cocaine, leading to long-term potentiation. Gene expression and synaptic activity are reported to recover within the first 24 hours post cocaine exposure, but a memory of the first insult is thought to prevail, as a second exposure leads to more expansive activation. To gain mechanistic insights into the chromatin structure alterations seen by 24h and understand the cascade of events that disturbs networks of regulatory sequences and genes, we
ePoster · Neuroscience