A single dose of cocaine rewires the 3D genome structure of midbrain dopamine neurons
Dominik Szabo, Vedran Franke, Simona Bianco, Mykhailo Batiuk, Eleanor Paul, Alexander Kukalev, Ulrich Pfisterer, Ibai Irastorza-Azcarate, Andrea Chiariello, Samuel Demharter, Luna Zea-Redondo, Jose Lopez-Atalaya, Mario Nicodemi, Altuna Akalin, Konstantin Khodosevich, Mark Ungless, Warren Winick-Ng, Ana Pombo · FENS Forum 2024
Cocaine and other addictive drugs are known to cause sensitization, a reinforced behavioral response to repeated exposures to the same drug, eventually contributing to compulsive use. The sensitized response is maintained for several weeks of abstinence, and outlasts transient transcription-dependent changes in neuronal physiology and plasticity. Due to its complex properties, the 3D structure of the genome may undergo long-lasting changes upon a single drug exposure, and serve as cellular memory in the path to addiction. Here, we show that a single exposure to cocaine induces extensive rewiri
ePoster · Neuroscience