Evaluating the spread of excitation with different types of optogenetic cochlear stimulation through computer simulations and in vivo electrophysiology
Elisabeth Koert, Jonathan Götz, Bettina Wolf, Tobias Moser · FENS Forum 2024
The optical cochlear implant (oCI) utilizes optogenetic stimulation of the spiral ganglion neurons (SGNs) in the cochlea to improve hearing restoration. Preclinical data has shown that this may improve bionic hearing in CI users by targeting smaller areas of the cochlea compared to electrical stimulation.This study investigates the influence of the light emitter characteristics (one/two laser-coupled glass fibers) on the spread of excitation, through a combination of computer simulations and in-vivo multiunit recordings of inferior colliculus activity in Mongolian gerbils that postnatally rece
ePoster · Neuroscience