Method for 3D quantitative analysis of enteric nervous system remodeling in mouse and human gut tissues
Arielle Planchette, Ivana Gantar, Yoseline Cabara, Jules Scholler, Aleksander Sobolewski, Stéphane Pagès, Michalina Gora · FENS Forum 2024
The involvement of the Enteric Nervous System (ENS), the gut’s brain, in digestive and neurological disorders is widely recognized and constitutes a novel target for diagnostic biomarkers and therapies. For example, Parkinson’s disease patients are now stratified according to gut-first or brain-first patterns that diverge in symptom progression. However, large-scale characterization of this neuronal network is often limited to dissected micrometer-scale samples that cannot reflect network changes. We present a method for 3D quantitative analysis of ENS morphology using fluorescence lightsheet
ePoster · Neuroscience