Nucleoporin 153 deficiency in adult neural stem cells defines a pathological protein-network signature and defective neurogenesis in a mouse model of Alzheimer’s disease
Alessia Bertozzi, Claudia Colussi, Marco Rinaudo, Lucia Leone, Federica Conte, Giuseppe Aceto, Domenica Donatella Li Puma, Cristian Ripoli, Raimondo Sollazzo, Maria Gabriella Vita, Marcello D'Ascenzo, Claudio Grassi · FENS Forum 2024
Reduction of adult hippocampal neurogenesis is an early critical event in Alzheimer’s disease (AD), leading to progressive memory loss and cognitive decline.The nucleoporin Nup153, besides its role in nuclear transport, has been described as a key regulator of NSC plasticity through gene modulation. Here we investigated the potential role of Nup153 as target to improve neurogenesis in the 3xTg mouse model of AD in vitro and in vivo.We found that reduced Nup153 levels characterized NSCs from the 3xTg mice (AD-NSCs) and caused inefficient proliferation, migration and differentiation that were re
ePoster · Neuroscience