Topic: α5-GABAARs

Spontaneous network activity is a conserved feature of the developing brain, and accumulating evidence indicates that it plays a critical role in neuronal circuit maturation. In the neonatal mouse hippocampus, spontaneous network activity in vitro comprises intermittent giant depolarizing potentials (GDPs) that alternate with periods of asynchronous activity. Spontaneous activity depends on depolarizing GABA, mediating mixed excitatory and inhibitory actions. However, little is known about how different GABAA receptor (GABAAR) subunit compositions contribute to spontaneous activity. Here, we i