NLX-101, a 5-HT1A receptor biased agonist, attenuates executive function impairments in mice
Angelika Jagielska, Sameh Abouzahra, Aleksandra Koszałka, Klaudia Lustyk, Marcin Kołaczkowski, Adrian Newman-Tancredi, Karolina Pytka · FENS Forum 2024
Depression is a serious mental illness that includes both behavioral symptoms and cognitive dysfunction. With the growing problem of ineffective treatment, there is a constant need for compounds with rapid antidepressant and procognitive effects. A compound that has shown antidepressant-like activity after single administration in animal models is NLX-101. NLX-101 preferentially activates postsynaptic 5-HT1A heteroreceptors in the prefrontal cortex, stimulating extracellular signal-regulated kinase (ERK1/2) phosphorylation. Thus, this study aimed to evaluate the potential ability of NLX-101 to
ePoster · Neuroscience