Brain activation patterns during memory processes measured with functional magnetic resonance imaging are associated with human serotonin-1A receptor in vivo
Matej Murgaš, Pavle Mićić, Christian Milz, Andreas Hahn, Rupert Lanzenberger · FENS Forum 2024
The serotonergic system was previously shown to affect learning and memory processes in humans[1]. Establishing a relation between serotonin-1A receptor (5-HT1AR) distribution with memory processing would allow us to further investigate its potential as a therapeutic target. Here, we aim to investigate the effect of 5-HT1AR spatial distribution on the different memory domains. Positron emission tomography data were collected from 20 healthy volunteers using the radioligand [carbonyl-11C]WAY-100635 [2,3]. Data were quantified using multilinear reference tissue model 2 to obtain non-displaceable
ePoster · Neuroscience