Topic: 5-HTT

The apoptotic removal of superfluous neurons during early brain development is strongly regulated by neuronal activity. This suggests that with emergent neuronal network activity cell death unfolds with precise temporal control but also in a region- and cell-specific manner. In order to map programmed death in the developing mouse cerebral cortex, tissue clearing, immunohistochemistry and light sheet microscopy were applied. Activated-caspase-3 (aCasp3), nuclear SYTOX as well as 5-HTT signals were then used to register the distribution of apoptotic cells across cortical regions and layers.Whil