Serotonin regulates immune cell infiltration to the brain compartment
Dorit Farfara Cohen, Peter Androvic, Katrin Perez Anderson, Margarita Sirotkin, Ben Korin, Hilla Azulay-Debby, Ozgun Goekce, Asya Rolls · FENS Forum 2024
The entry of peripheral immune cells into brain border areas like the choroid plexus and meningesis established, but the mechanism regulating their infiltration and functional role is not fullyunderstood. Our study sheds light on the role of serotonin in the migration of these cells and theirinvolvement in the action of selective serotonin reuptake inhibitors (SSRIs). We found thatfluoxetine (FLX), which is known to boost available serotonin, led to a higher number of immunecells found in the brain (parenchyma and borders) of socially isolated mice. By employing spatial transcriptomics and sin
ePoster · Neuroscience